Multiple Sclerosis Gene Therapy Using Recombinant Viral
Vectors: Overexpression of IL-4, IL-10 and Leukemia
Inhibitory Factor in Wharton’s Jelly Stem Cells in
The EAE Mice Model
Immunotherapy and gene therapy play important roles in modern medicine. The aim of this study is to evaluate the overexpression of interleukin-4 (IL-4), IL-10 and leukemia inhibitory factor (LIF) in Wharton’s jelly stem cells (WJSCs) in the experimental autoimmune encephalomyelitis (EAE) mice model.
Materials and Methods
In this experimental study, a DNA construction containing
Isolated WJSCs were performed to characterize by
These results showed that gene therapy using anti-inflammatory cytokines can be a promising approach against multiple sclerosis (MS). In addition, considering the immunomodulatory potential of WJSCs, an approach using a combination of WJSCs and gene therapy will enhance the treatment efficacy.