Effect of (R)-(+) Pulegone on Ovarian Tissue; Correlation
with Expression of Aromatase Cyp19 and Ovarian
Selected Genes in Mice
Pulegone (PGN) is a monoterpene ketone, whose metabolites exert several cytotoxic effects in various tissues. The present study was conducted in order to evaluate the (R)-(+) PGN-induced alterations in ovarian aromatization, proto-oncogenes and estrogen receptorα (ERα) and ERβ receptors expressions.
Materials and Methods
In this experimental study, mature albino mice were divided into experimental (received
25 mg/kg, 50 mg/kg and 100 mg/kg PGN, orally for 35 days) and control (received 2% solution of Tween 80
as a PGN solvent, orally) groups. The mRNA levels of
The PGN reduced
Chronic exposure to PGN (50 mg/kg and 100 mg/kg), severely affects ovarian aromatization, proto- oncogenes mRNA levels and expression of ERs.