Crab Shell Extract Induces Prostate Cancer Cell Line
(LNcap) Apoptosis and Decreases Nitric
Prostate cancer is the second most common cancer worldwide. Chemotherapeutic
agents have been shown to have adverse side-effects, and natural compounds
have been recommended for cancer treatment, nowadays. Crab shell has been shown to
have cancer preventative and suppressive effects
Materials and Methods
LNcap viability was decreased dose- and time-dependently. Thus 400, 800, and 1000 µg/ml doses showed significant differences compared to control group (P<0.001). Dose-dependent increase in the apoptotic index was also observed in 800 and 1000 µg/ ml concentrations (P<0.001). Nitric oxide secretion of LNcap cell was decreased time- and dose-dependently, while it was significant for 1000 µg/ml (P<0.05).
Crab shell extract showed anti-prostate cancer effect, by inducing cell apop- tosis and decreasing NO production.