Advanced Glycation End-Products-, C-Type Lectin- and Cysteinyl/
Leukotriene-Receptors in Distinct Mesenchymal Stromal Cell
Populations: Differential Transcriptional Profiles in Response to
*The first two authors equally contributed to this article.
We aimed at characterizing the transcription profiles of immunological receptors associated with the biology of mesenchymal stromal cells (MSCs).
Materials and Methods
In this experimental study, quantitative real time-polymerase chain reaction (qRT-
PCR) was performed to establish the transcription profiles of advanced glycation end-products (
MSCs derived from adipose tissue (AT), foreskin (FSK), Wharton’s jelly (WJ) and bone marrow (BM) exhibited significantly different transcription levels for these genes. Interestingly, these transcription profiles substantially changed following exposure of MSCs to inflammatory signals.
Collectively, for the first time, our data highlights that MSCs depending on their tissue-source, present several relevant receptors potentially involved in the regulation of inflammatory and immunological responses. Understanding the roles of these receptors within MSCs immunobiology will incontestably improve the efficiency of utilization of MSCs during cell-based therapies.