Modulating Effects of Spirulina platensis against
Tilmicosin-Induced Cardiotoxicity in Mice
#Both authors equally contributed to this work.
Tilmicosin (TIL) is a long-acting macrolide antibiotic used to treat cattle for
pathogens that cause bovine respiratory disease. However, overdoses of this medication
have been reported to induce cardiac damage. Our experimental objective was to evaluate the protective effects of
Materials and Methods
TIL treated animals showed a significant increase in serum cardiac injury biomarkers as well as cardiac lipid peroxidation, however they had evidence of an inhibition in antioxidant biomarkers. SP normalized elevated serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), and CK-MB. Furthermore, SP reduced TIL-induced lipid peroxidation and oxidative stress in a dose-dependent manner.
Administration of SP minimized the toxic effects of TIL by its free radicalscavenging and potent antioxidant activity.