The Effect of Biomaterials on Human Dental Pulp Stem Cell Neural Differentiation: A Scoping Review

Document Type : Systematic Review

Authors

1 Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran

2 Social Determinants of Health Research Centre, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

3 Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

4 Nanoclub Elites Association, Tehran, Iran

5 Universal Scientific Education and Research Network (USERN), Sanandaj, Iran

6 Cellular and Molecular Research Centre, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

7 Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

8 Department of Medical Genetics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

9 Department of Psychiatry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

10 Neurosciences Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

Abstract

Neural cells are the most important components of the nervous system and have the duty of electrical signal transmission.
Damage to these cells can lead to neurological disorders. Scientists have discovered different methods, such as stem cell
therapy, to heal or regenerate damaged neural cells. Dental stem cells are among the different cells used in this method.
This review attempts to evaluate the effect of biomaterials mentioned in the cited papers on differentiation of human dental
pulp stem cells (hDPSCs) into neural cells for use in stem cell therapy of neurological disorders. We searched international
databases for articles about the effect of biomaterials on neuronal differentiation of hDPSCs. The relevant articles were
screened by title, abstract, and full text, followed by selection and data extraction. Totally, we identified 731 articles and chose
18 for inclusion in the study. A total of four studies employed polymeric scaffolds, four assessed chitosan scaffolds (CS),
two utilised hydrogel scaffolds, one investigation utilised decellularised extracellular matrix (ECM), and six studies applied
the floating sphere technique. hDPSCs could heal nerve damage in regenerative medicine. In the third iteration of nerve
conduits, scaffolds, stem cells, regulated growth factor release, and ECM proteins restore major nerve damage. hDPSCs
must differentiate into neural cells or neuron-like cells to regenerate nerves. Plastic-adherent cultures, floating dentosphere
cultures, CS, polymeric scaffolds, hydrogels, and ECM mimics have been used to differentiate hDPSCs. According to
our findings, the floating dentosphere technique and 3D-PLAS are currently the two best techniques since they result in
neuroprogenitor cells, which are the starting point of differentiation and they can turn into any desired neural cell.

Keywords

Main Subjects

References

  1. Biehl JK, Russell B. Introduction to stem cell therapy. J Cardiovasc Nurs. 2009; 24(2): 98-103.
  2. Kang YH, Shivakumar SB, Son YB, Bharti D, Jang SJ, Heo KS, et al. Comparative analysis of three different protocols for cholinergic neuron differentiation in vitro using mesenchymal stem cells from human dental pulp. Anim Cells Syst (Seoul). 2019; 23(4): 275-287.
  3. Gao Y, Tian Z, Liu Q, Wang T, Ban LK, Lee HH, et al. Neuronal cell differentiation of human dental pulp stem cells on synthetic polymeric surfaces coated with ecm proteins. Front Cell Dev Biol. 2022; 10: 893241.
  4. Bongso A, Richards M. History and perspective of stem cell research. Best Pract Res Clin Obstet Gynaecol. 2004; 18(6): 827- 842.
  5. Pisciotta A, Bertoni L, Riccio M, Mapelli J, Bigiani A, La Noce M, et al. Use of a 3D floating sphere culture system to maintain the neural crest-related properties of human dental pulp stem cells. Front Physiol. 2018; 9: 547.
  6. Bojnordi MN, Haratizadeh S, Darabi S, Hamidabadi HG. Neural derivation of human dental pulp stem cells via neurosphere technique.Bratisl Lek Listy. 2018; 119(9): 550-553.
  7. Zheng K, Feng G, Zhang J, Xing J, Huang D, Lian M, et al. Basic fibroblast growth factor promotes human dental pulp stem cells cultured in 3D porous chitosan scaffolds to neural differentiation. Int J Neurosci. 2021; 131(7): 625-633.
  8. Laudani S, La Cognata V, Iemmolo R, Bonaventura G, Villaggio G, Saccone S, et al. Effect of a bone marrow-derived extracellular matrix on cell adhesion and neural induction of dental pulp stem cells. Front Cell Dev Biol. 2020; 8: 100
  9. Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S. Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells. 2008; 26(7): 1787-1795.
  10. Adriztina I, Munir D, Sandra F, Ichwan M, Bashiruddin J, Putra IB, et al. Differentiation capacity of dental pulp stem cell into inner ear hair cell using an in vitro assay: a preliminary step toward treating sensorineural hearing loss. Eur Arch Otorhinolaryngol. 2022; 279(4): 1805-1812.
  11. Gonmanee T, Thonabulsombat C, Vongsavan K, Sritanaudomchai H. Differentiation of stem cells from human deciduous and permanent teeth into spiral ganglion neuron-like cells. Arch Oral Biol. 2018; 88: 34-41.
  12. Ghasemi Hamidabadi H, Rezvani Z, Nazm Bojnordi M, Shirinzadeh H, Seifalian AM, Joghataei MT, et al. Chitosan-intercalated montmorillonite/poly(vinyl alcohol) nanofibers as a platform to guide neuronlike differentiation of human dental pulp stem cells. ACS Appl Mater Interfaces. 2017; 9(13): 11392-11404.
  13. Zhang J, Lu X, Feng G, Gu Z, Sun Y, Bao G, et al. Chitosan scaffolds induce human dental pulp stem cells to neural differentiation: potential roles for spinal cord injury therapy. Cell Tissue Res. 2016; 366(1): 129-142.
  14. Pineda JR, Polo Y, Pardo-Rodríguez B, Luzuriaga J, Uribe-Etxebarria V, García-Gallastegui P, et al. In vitro preparation of human Dental Pulp Stem Cell grafts with biodegradable polymer scaffolds for nerve tissue engineering. Methods Cell Biol. 2022; 170: 147- 167.
  15. Feng X, Lu X, Huang D, Xing J, Feng G, Jin G, et al. 3D porous chitosan scaffolds suit survival and neural differentiation of dental pulp stem cells. Cell Mol Neurobiol. 2014; 34(6): 859-870.
  16. Luo L, He Y, Jin L, Zhang Y, Guastaldi FP, Albashari AA, et al. Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries. Bioact Mater. 2020; 6(3): 638-654.
  17. Hsiao D, Hsu SH, Chen RS, Chen MH. Characterization of designed directional polylactic acid 3D scaffolds for neural differentiation of human dental pulp stem cells. J Formos Med Assoc. 2020; 119(1 Pt 2): 268-275.
  18. Drewry MD, Dailey MT, Rothermund K, Backman C, Dahl KN, Syed-Picard FN. Promoting and orienting axon extension using scaffold-free dental pulp stem cell sheets. ACS Biomater Sci Eng. 2022; 8(2): 814-825.
  19. Farhang S, Soleimani M, Ostadsharif M, Ghasemi N. Neurogenic induction of human dental pulp derived stem cells by hanging drop technique, basic fibroblast growth factor, and SHH factors. Dent Res J (Isfahan). 2021; 18: 57.
  20. Rafiee F, Pourteymourfard-Tabrizi Z, Mahmoudian-Sani MR, Mehri-Ghahfarrokhi A, Soltani A, Hashemzadeh-Chaleshtori M, et al. Differentiation of dental pulp stem cells into neuron-like cells. Int J Neurosci. 2020; 130(2): 107-116.
  21. Goudarzi G, Hamidabadi HG, Bojnordi MN, Hedayatpour A, Niapour A, Zahiri M, et al. Role of cerebrospinal fluid in differentiation of human dental pulp stem cells into neuron-like cells. Anat Cell Biol. 2020; 53(3): 292-300.
  22. Geng YW, Zhang Z, Liu MY, Hu WP. Differentiation of human dental pulp stem cells into neuronal by resveratrol. Cell Biol Int. 2017; 41(12): 1391-1398.
  23. Martens W, Sanen K, Georgiou M, Struys T, Bronckaers A, Ameloot M, et al. Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro. FASEB J. 2014; 28(4): 1634-1643.
  24. Yang C, Li X, Sun L, Guo W, Tian W. Potential of human dental stem cells in repairing the complete transection of rat spinal cord. J Neural Eng. 2017; 14(2): 026005
  25. Mu X, Liu H, Yang S, Li Y, Xiang L, Hu M, et al. Chitosan tubes inoculated with dental pulp stem cells and stem cell factor enhance facial nerve-vascularized regeneration in rabbits. ACS Omega. 2022; 7(22): 18509-18520.
  26. Solis-Castro OO, Boissonade FM, Rivolta MN. Establishment and neural differentiation of neural crest-derived stem cells from human dental pulp in serum-free conditions. Stem Cells Transl Med. 2020; 9(11): 1462-1476.
  27. Matsumura H, Marushima A, Ishikawa H, Toyomura J, Ohyama A, Watanabe M, et al. Induced neural cells from human dental pulp ameliorate functional recovery in a murine model of cerebral infarction. Stem Cell Rev Rep. 2022; 18(2): 595-608.
  28. Hu ZB, Chen HC, Wei B, Zhang ZM, Wu SK, Sun JC, et al. Platelet rich plasma enhanced neuro-regeneration of human dental pulp stem cells in vitro and in rat spinal cord. Ann Transl Med. 2022; 10(10): 584.
  29. Pham TTM, Kato H, Yamaza H, Masuda K, Hirofuji Y, Sato H, et al. Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndrome. BMC Neurol. 2018; 18(1): 132.
  30. Gnanasegaran N, Govindasamy V, Kathirvaloo P, Musa S, Abu Kasim NH. Effects of cell cycle phases on the induction of dental pulp stem cells toward dopaminergic-like cells. J Tissue Eng Regen Med. 2018; 12(2): e881-e893.
Cell Journal (Yakhteh)
Volume 25, Issue 12 - Serial Number 119
December 2023
Pages 813-821

Files

Share

How to cite

Statistics