Ps-78: Stem Cell Treatment for Childhood Absence Epilepsy


Norouzbeygie A *, Saeedian N ,

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Objective: Epilepsy is a brain disorder involving repeated and spontaneous seizures. Epilepsy is also called seizure disorder. A seizure occurs when a surge of electrical activity affects part of the brain. Seizures can have many symptoms and can last from a few seconds to several minutes. They are typically characterized by a loss of consciousness and convulsions. Childhood absence epilepsy (CAE) presents between ages 3 and 5 years and usually remits by ages 10-12 years. Childhood absence epilepsy is usually not associated with tonic-colonic seizures. Electroencephalography (EEG) shows a normal background for age and 3-Hz generalized spike and wave discharges. In this study we want to characterize the effect of stem cells for treatment the childhood absence epilepsy. Materials and Methods: In this study we selected 12 children (2-6 years old) with a history of epilepsy for more than 6 month that treatment with stem cells implantation (stem cells contain NPY, an anticonvulsant agent that exists in the healthy human brain) in tow procedures, one of them for 7weeks, and the other on after 6 months. EEG, the symptoms of epilepsy and duration are observed and notated before and after stem cell therapy. Results: In 9 patients seizures are much more under control, and 3 children only had seizures 5-10 times per day, and they last only 1-2 seconds. In all patients EEG was changed and generalized spike and wave discharges decreased. Conclusion: Plasticity of embryonic stem cells can help to repair brain cells that have been damaged by repeated seizures. Seizure disorders are characterized by the hyper excitability of different types of brain cells, meaning they are more susceptible than healthy brain cells to electrical storms