Ps-123: Roles of The Injection of Fibroblast Growth Factor-2 and Neuregulin-1 on Stimulation of Stem Cell Migration on Sub Ventricular Zone


Lotfinia M *, Khodaei B , Lotfinia A , Ahmadi M ,

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Objective: Progenitor cells in the sub ventricular zone of the lateral ventricle can proliferate throughout the life of the animal. Neurons progenitor cells are highly sensitive to ischemic strokes. Materials and Methods: Recent evidence points to a relationship between neuregulin-1(Nrg-1) and the process of neural cells differentiation. Fibroblast growth factor- 2 (FGF-2) and its multiple high-affinity FGF receptors (FGFRs) are regulating neural differentiation and migration mainly by controlling precursor cells proliferation. This study was aimed to evaluate the combination of FGF-2 and Nrg-1 sub ventricular zone injection on progenitor cells migration. Middle cerebral artery (MCA) Ischemic stroking and precursor cells labeling by injection of bromodeoxyuridine (BrdU) in sub ventricular zone were suggested. Results: A remarkable increase expected 4 weeks after injection of FGF-2 and Nrg-1 factors in the number of labeled cells in olfactory bulb by immunohistochemistry method. Conclusion: On the basis of these findings, we hypothesized that simultaneous injection of FGF-2 and Nrg- 1cause enhancement on the amount of sub ventricular zone precursor cells migration.