I-10: Helping T Cells to Fight Cancer


Habibagahi M *,

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The pro-tumor activity of immune system is a potential risk for application of immunotherapy and this risk could be much higher in some modalities. Among different approaches for immunotherapy, recruitment of immune costimulatory molecules, in forms of cancer vaccines to enhance immune stimulation or in ex vivo T cell expansion methods, has been an attractive method. However, the exploitation of different groups of these molecules has shown a mixture of results. Many groups have put 4-1BB (CD137), of TNFR super-family, under the spotlight and demonstrated promising results about its activity from various perspectives. Some of the findings on pan-T cell activation, Ag-specific expansion or animal models of application of 4-1BBL or anti- CD137 antibodies will be presented and discussed