I-14: The Structure and Function of Membrane Proteins


Khademi Sh *, Gray L , Akgun U , Toliat A ,

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The fact that ~%60 of drug receptors are membrane proteins shows the importance of membrane proteins in drug discovery research. Although 25-30% of the genes in cells encode membrane proteins, less than 0.5% of the proteins with known structures (deposited in PDB bank) are membrane proteins. While this reflects the difficulty of expression, purification, and crystallization of membrane proteins, it also emphasizes the importance of investigating the structures and functions of these biologically important proteins. Most membrane proteins fall into two general categories; transporters (and channels) and receptors. Some proteins serve both of these functions simultaneously. The focus of our Abstract of the 1st Int. Student Congress on Cell & Molecular Medicine Cell Journal(Yakhteh), Vol 12, Suppl 1, Winter 2011 14 research is the structure and function of biologically important channels and transporters. The structure and mechanism of ammonia channel and urea channel will be presented