O-2: Altered Activation of Glutathion Peroxidase and Glutathione Reductase: A Possible Mechanism for Gingival Overgrowth in Patients Receiving Cyclosporine A (CsA (Pages: 18-19)

Sardarian AR *, Zal F , Andishetadbir A , Amini F , Mostafavi-Pour Z ,


Gingival overgrowth (GO) occurs frequently in patients receiving cyclosporine A (CsA), as an immunosuppressant therapy, following renal transplantation. GO is characterized by enlargement of the gingiva with epithelial thickening and overproduction of extracellular matrix components. The pathogenesis of the epithelial thickening in GO is probably multifactorial and still remains obscure. Since it has been shown that the oxidative stress is one of the possible mechanisms of CsA-induced nephrotoxicity and hepatotoxicity, in this study we aimed to investigate whether the effect of CsA on the gingiva is via changing the activation patterns of Glutathion peroxidase (GPx) and glutathione reductase (GR). For this purpose we used an in vitro model, oral epithelial cells, in an attempt to identify the cellular mechanisms underlying gingival CsA damage