O-3: The Possible Role of HSPs on Behçet's Disease: A Bioinformatic Spproach (Pages: 18-19)

Dabbagh f *, Ghasemi Y , Morowvat MH , Rasoul-Amini S , Borhani Haghighi A ,


Current evidence lends increasing support to immunoinflammatory mechanisms as one of the prime pathogenic processes involved in the development and progression of Behçet’s disease (BD). It has Oral Presentations Cell Journal(Yakhteh), Vol 12, Suppl 1, Winter 2011 19 been observed that most human beings have cellular and humoral reactions against microbial heat shock proteins (HSP). Autoantibody levels against HSPs are significantly increased in patients with BD and T lymphocytes specifically responding to HSPs have been demonstrated in these patients. The observation that eukaryotic and prokaryotic HSPs have high sequence similarity promoted the hypothesis that HSPs might be potential candidates for molecular mimicry and could act as potentially dangerous autoantigens.