O-6: Dating the Adaptation of H1N1 and H3N2 Subtypes of Influenza A Viruses in Different Hosts


Rahnama L *, Aris-Brosou S ,

0

Influenza A viruses cause the death of 250,000 to 500,000 people annually, and up to 50 millions during pandemic years. This virus has the potential to be transmitted from nonhuman hosts to humans, and vice versa. But, following a host switch event, the nucleotide composition of the virus might differ from that of its new host, which leads to an inefficient replication of the virus and therefore a suboptimal viral fitness. Therefore, we predict that after such a host switch event, the nucleotide composition of the virus should change to reflect that of its new host to maximize the virus fitness. However, the dynamics of this evolutionary change across different hosts and viral subtypes remain unknown. We hypothesize that viral adaptation time to its new host is independent of the host and of the viral subtype