O-22: Derivation of Insulin Producing Cell from Mesenchymal Stem Cells Using Lentiviruses Harboring pdx1 (Pages: 28-29)

Talebi S *, Aleyasin A , Soleimani M , Massumi M ,


Type1 diabetes is generally caused by insulin deficiency because of destruction of islet beta cells and differentiated mesenchymal stem cells (MSCs) can be therapeutic source for the cure of type 1 diabetes. The aim of current experiment is to explore the possibility of derivation of insulin producing cells from bone marrow mesenchymal stem cells in vitro by overexpression of pdx1 transcription factor.