P-8: Evaluation of Serum Paraoxonase Activity in Patients with Psoriasis


Khoshnoodi M *, Hashemi M , Daliri M ,

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Objective: Psoriasis is a common inflammatory skin disease which is characterized by marked increase in keratinocyte proliferation and abnormal pattern of keratinocyte differentiation with unknown etiology. There are studies about oxidative stress with increasing reactive oxygen species (ROS) and reduced antioxidant system that involved in the pathogenesis of psoriasis. Paraoxonase (PON) is an enzyme that seems to have a relevant role in detoxifying processes and performs as an antioxidant agent however, the exact role of PON is still unclear. The aim of the present study was to determine serum paraoxonase activity in psoriatic patients and healthy subjects. Materials and Methods: This case-control study was performed on 32 patients with psoriasis and 49 healthy subjects. Serum paraoxonase activity were determined spectrophotometrically with Paraoxone as substrate. Results: Serum paraoxonase (PON) activity in psoriatic and normal subjects were 79.53 ± 70.76 IU/L and 71.01 ± 59.97 IU/L, respectively. There were no significant difference between the groups regarding PON activity (p=0.55). Conclusion: Our data indicated that there is no difference between Serum paraoxonase activity in psoriatic and normal subjects. We suggest further studies focus on arylesterase activity and paraoxonase gene polymorphisms in patients with psoriasis