P-16: Survey of Association between Helicobacter Pylori and Hepatocellular Carcinoma in the Specimens Drived from Health Centers of Shahid Beheshti University


Fotouhi M *, Eslami G , Peirovi H , Hashemibahramani M , Jafarpour M , Douraghi M , Amadzadeh E ,

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Objective: In recent years, the attention has been drown to the possible association of Helicobacter infections not only with upper gastrointestinal tract disease but also with several extra-gastrointestinal disease e.g liver and biliary disease. Helicobacter species have been isolated from the liver samples of a variety of mammals, the role of which has been documented in the chronic hepatitis and various types of liver carcinoma. Hepatocellular carcinoma in the third cause of cancer death worldwide. Each year, more than 626000 cases of Hepatocellular carcinoma are reported. Because there is no proper diagnostic method for it, more than 598000 people lose their life. This tumor often follows chronic liver inflammation and cirrhosis. Materials and Methods: We collected 40 liver specimens from two health center of shahid beheshti university, including 22 specimens of Hepatocellular carcinoma and 18 specimens of cirrhosis. In this study, for determining the presence of Helicobacter pylori in liver samples we used polymerase chain reaction. Results: 16S rRNA of Helicobacter genous were found from 31.8% of Hepatocellular carcinoma and 16.7% of cirrhosis. Conclusion: Helicobacter infection exists in liver of patients with Hepatocellular carcinoma. Association between H.pyori and Hepatocellular carcinoma needs further research