Objective: Epidermal growth factor receptor (EGFR/ErbB1) is a member of the ERBB family of receptor tyrosin kinase that regulates cell growth and apoptosis. EGFR is correlated with development and progression of tumors and its expression has played an important role in colorectal cancer. In this study, we assessed EGFR expression and it’s relation to clinicopathologic significances in colorectal adenocarcinoma patients. Materials and Methods: Paraffin-embedded specimens of 50 patients with colorectal adenocarcinoma were studied by immunohistochemistry for the assessment of EGFR expression. The findings were correlated with the clinicopathologic variables of colorectal tumor tissues. Results: Membranous EGFR expression was found in 24(48%) of cancer specimens. According to multivariate analysis, EGFR expression was no significantly associated with age, sex, tumor site, stage, grade and type of tumor in cases. Conclusion: These results suggest that assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry can not be useful to predict about outcome of patients.