Past Issue

Volume 12, Supplement 1,Winter 2011 (Presented at The 1st International Student Congress) Pages: 60-61

P-46: Cytogenetic Results of Infertile Patients Referred to Cytogenetic Laboratory of Jahad Daneshgahi of Tabriz


Objective: Infertility is a multifactorial disorder that can be caused by chromosomal abnormalities.Generally worldwide it is estimated that one in seven couples have problems conceiving with the incidence similar in most countries independent of the level of the country’s development. In this study we aimed to investigate the frequency of chromosal abnormalities among the patiens referred to cytogenetic laboratory of Jahad daneshgahi in tabriz. Materials and Methods: Chromosomes from cultured peripheral blood lymphocytes of 240 patients, composed of 81 women and 158 men, were analysed using GTG banding. The study took place during 1385 to 1389. Results: Chromosome abnormality was found in 20 cases and the total rate of abnormality was 8.33%. The most frequent abnormality among infertile men was Klinefelter’s syndrome (47, XXY) which was detected in 11 patient.Two of them had a mosaic karyotype (46, XY/47, XXY). Deletion on q arm of chromosome Y, an inversion on chromosome 9, sex reversal and heteromorphisms were the other abnormalities among the infertile men. The most prevelent abnormality among the infertile women was Turner syndrome (45, XO)that was found in 3 cases while one of them had mosaic karyotype (46, XX/45, XO). Conclusion: The present study shows that chromosal abnormality is a significant factor leading to fertility problems .It confirms the necessity of cytogenetic analysis in infertile patients