P-51: The Association Study of XRCC1 Gene Single Nucleotide Polymorphisms with Response to Chemotherapy in Locally Advanced Breast Cancer


Khalili Avati M *, Saadat I , Omidvari S , Saadat M ,

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Objective: Primary treatment in locally advanced breast cancer is chemotherapy. A different response to similar chemotherapy schemes is one of the problems in this type of treatment. Among factors responsible for this variability, genetic variation plays important roles. The aim of present cohort study was to investigate the effect of genetic polymorphisms in XRCC1 gene (399 and 194 codons) on response to chemotherapy-based treatment. Materials and Methods: DNA was extracted from peripheral blood of 98 patients with locally advanced breast cancer. Genotypes were determined using a RFLP-PCR method for XRCC1 polymorphisms. Also information about tumor size after each cycle of chemotherapy was gathered from patient’s dossier. Results: No significant association was obtained between XRCC1 Arg399Gln (χ2= 0.225, p=0.894) and Arg194Trp (χ2= 0.485, p=0.784) polymorphisms and response rate to treatment. Conclusion: According to this finding, polymorphisms in XRCC1 gene had no effect on response rate to chemotherapy in locally advanced breast cancer. Therefor exclude a role for XRCC1 polymorphisms (399 and 194 codons) as a prognostic factor in locally advanced breast cancer