P-61: Angiotensinogen M235T Polymorphism is Associated with Preeclampsia in Iranian Pregnant Women (Pages: 67-67)

Salehi O *, Roozbeh J , Ghaedi M , Samsami Dehaghani A , harifian M , Godarzi H , Afshariani R ,


Objective: Preeclampsia is a complication of pregnancy characterized by increased vascular resistance pressure, proteinuria and edema that appears in the second and third trimesters of pregnancy. To test this hypothesis that angiotensinogen gene polymorphism influences the incidence, development and outcome of preeclampsia, we analysis the M235T mutation in the gene encoding angiotensinogen. The aim of this study is to determine if there is an association between the M235T variant of angiotensinogen gene and preeclampsia in Iranian preeclamtic women with hypertension during pregnancy. Materials and Methods: In the present study, we used PCR-RFLP analysis to investigate the association between M235T polymorphism in preeclamtic women compared to normotensive controls. Results: The M235T polymorphism was significantly associated with increased preeclampsia risk in the studied population as supported by a P value 0.017 and Chisquare equal to 8.12. The frequency of mutated allele and genotype distribution showed a significant difference between preeclamtic women and control groups. Conclusion: The result indicates that the AGT M235T polymorphism play significant role in preeclampsia observed in selected Iranian preeclamtic women, and it can be considered a major risk factor for preeclampsia