Objective: Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes. Present study was carried out to evaluate the possible association of adiponectin gene polymorphisms in diabetic and non-diabetic Iranian population. Materials and Methods: This study involved two cross sectionals: 243 diabetic patients and 173 non-diabetic subjects who were recruited from Rafsanjan city in south – east of Iran. The possible association of +45T/G and –11391G/A adiponectin gene polymorphisms with BMI (Body Mass Index ), waist circumferences (WC) and blood pressure was evaluated. Results: No significant association was found between +45T/G and –11391G/A polymorphisms of adiponectin gene with systolic or diastolic blood pressure according to gender differences. The male carriers of TT genotype of +45T/G have significantly higher mean BMI than male GG homozygotes (p = 0.018). Additional, male carriers of the GG genotype of –11391G/A had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). We observed the female carriers of the GG genotype of –11391G/A had significantly higher mean waist circumference than female GA or AA homozygotes (p = 0.038). Conclusion: There was no significant change in mean systolic or diastolic blood pressure among men or women carriers of different genotypes of the + 45G/T and – 11391 G/A adiponectin gene polymorphisms. But the effect of presence diabetes was significant on increasing systolic or diastolic blood pressure and this effect was independent of carriers. Although, mean BMI was significant high in females and diabetics, but low in GG carriers of +45T/G, and the mean WC was significant low in females and GG carriers of +45T/G. We found a significant high BMI in females, diabetics and GA or AA carriers of – 11391G/A polymorphism. But we observed significant low waist circumference in females and significant high waist circumference in GA or AA carriers of – 11391G/A polymorphism. We think there is a sex specific effect on BMI and WC in different carriers of +45T/G and –11391G/A polymorphisms independent of diabetes in our population.