P-69: Association of Angiotensin-Converting Enzyme (ACE) Gene A/G Polymorphism and Coronary Heart Disease (Pages: 71-71)

Abdolghafoorian H *, Ziai SA , Mirfakhrai R , Bina B , Hariri R ,


Objective: Cardiovascular diseases comprise the most prevalent serious disorders in industrialized nations and are a rapidly growing problem in developing nations. Coronary heart disease is still a major cause of death and is responsible for 40% of all deaths each year. The Angiotensin-Converting Enzyme (ACE) is one of the most studied candidate genes related to hypertension and ventricular hypertrophy. The aim of this study is to investigate the association of Angiotensin-Converting Enzyme (ACE) gene A/G polymorphism with coronary heart disease. Materials and Methods: This study is conducted in 212 Iranian patients of two groups: first group with established coronary heart disease and second control group. DNA was extracted from patients’ blood samples. Then the alleles of Angiotensin-Converting Enzyme (ACE) gene were detected using Polymerase Chain Reaction (PCR) and subsequent restriction digestion in all samples. Results: Angiotensin-Converting Enzyme (ACE) gene A/G polymorphism was higher in group with coronary heart disease.77% of first group had the G allele polymorphism and only 25% of control group had the G allele. Conclusion: Cardiovascular disease is now the most common cause of death worldwide. It has been shown that Angiotensin-Converting Enzyme (ACE) activity is associated with higher risk of hypertension and Diabetes Mellitus and hence, is a risk factor for coronary heart disease. In this study it is concluded that Angiotensin-Converting Enzyme (ACE) gene A/G polymorphism is associated with a higher risk of Coronary heart disease