P-77: Evaluation of Immune Cells in Patients with Onychomycosis (Pages: 74-74)

Haghani I *, Fathi M , Abedian S , Shokohi T , Yazdani J ,


Objective: Onychomycosis is the chronic fungal infection of the nails, which is very common. This disorder has a high prevalence among immunocompromised patients such as diabetics and hemodialysis patients. The essential role played by immune cells in the control of immunity against some pathogens is now well established. But their role in cutaneous fungal infections is still unknown. The aim of this study was to evaluate possible relationship of immune cells and onychomycosis. Materials and Methods: In this case-control study, Peripheral blood samples were investigated for immune cells using flow cytometry analysis in 20 onychomycosis patients and in 20 healthy controls. The relationship between groups and CD types was analyzed using General Linear Model analysis. In addition, we determined IgG level in those patients. Results: We have found that onychomycosis patients had a higher expression of CD4+ lymphocyte, CD8+ lymphocyte cells and IgG than controls. Mean±SD of CD4 percent as comparison with control are [32.81±11.15, (p=0.001)], CD8 percent [19.44±6.27, (p=0.004)], IgG percent [23.07±3.85, (p=0.001)], respectively. This study showed that statistically significant difference between Tests with controls. Conclusion: The results of this study suggests that increased numbers of CD4+, CD8+ cells may play a role in failure of clearance of dermatophytes from skin by preventing the protective inflammation which is leading to development of onychomycosis. Accordingly, we address the possibility that CD4+, CD8+ cells may play a role in immune pathogenesis of other superficial fungal infections