P-100: Multi Drug Resistant Staphylococcus Aureus Inhibited by Nano Bio-Glass Powder


Hosseinnejad F *, Amiri A , Hafezi F , Rahmani F , Imani Fooladi AA , Nourani MR ,

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Objective: Biodegradable polymer/bioactive glass (BG) composites in the form of scaffolds and membranes have been intensively studied because of their good biocompatibility and bioactivity as hard tissue regeneration materials. Bioactive silicate glasses (e.g. 45S5 BioglassR) with compositions in the system SiO2- Na2O-CaO-P2O5, having <55% SiO2 were discovered. The chemical compositions of the prepared samples were as predicted, and the particle size of the samples with an amorphous structure mainly ranged over 20-90 nm. Recently studied offer remarkable advantages as the inorganic components of composite scaffolds due to their high bioactivity index (Class A), and their ability to bond to both soft and hard connective tissues. Class A bioactive materials are osteogenetic and osteoconductive materials while Class B bioactive materials (such as hydroxyapatite) exhibit only osteoconductivity.[2] Certain bioactive glasses have been shown to exhibit antibacterial activity. The aim of this work was to evaluate the antibacterial effect of against the one of the most resistant bacteria Staphylococcus aureus by bioactive glass nanopowders. Materials and Methods: The composition of the studied bioactive glass belongs to the system SiO2-CaO-P2O5, Bioactive glass nano-powders were prepared using the sol-gel technique. Bioactive glass nano-powders were synthesized using the sol-gel technique. The prepared nanopowders mainly ranged between 20 and 90 nm in size. Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on standard and clinical multi drug resistant Staphylococcus aureus determined by MIC and MBC methods. Results: We found the antibacterial activity of bioactive glass in this study and This may result from one of the surface reactions. Particulate Bioglass is one example to exert a considerable antibacterial effect on standard and clinical multi drug resistant Staphylococcus aureus bacteria. Conclusion: The bioactive glass nano-powders showed the high antibacterial activity, therefore bioactive glass should be a suitable candidate for bio-implant scaffolds and prevent secondary infection after implantation