P-113: Effects of the Curcumin on the Dorsal Root Ganglion Structure and Functional Recovery after Sciatic Nerve Crush in Rat
Objective: Curcumin has been shown to have protective effects in a variety of CNS injury models. The purpose of this study was to assess the effects of the curcumin on the dorsal root ganglion (DRG) and functional recovery in an animal model of peripheral nerve crush. Materials and Methods: Sciatic nerve of the rats was crushed with a serrated hemostat. Twenty-eight days after injury the animals were deeply anesthetized and their right fifth lumbar DRG was removed. Stereological methods were used to assess the therapeutic effects of the curcumin (100 mg/kg body weight/day) on the DRG structure. Also sciatic functional index (SFI) of the rats were measured weekly for the evaluation of the functional recovery after sciatic nerve crush. Results: A- and B-cells volume reduced ~25% and ~33% and treatment with curcumin increased volume of these cells ~10% and 15% respectively. The surface of the A- and B-cells reduced ~23% and ~14% respectively after sciatic nerve crush. The number of A-, B- and satellite cells reduced ~51%, ~55% and ~32% and treatment with curcumin increased number of the cells ~10%, ~15% and ~19% respectively. In addition, as measured by the sciatic functional index, the motor function of the rats with curcumin treatment significantly improved at 21th days after sciatic nerve crush. Conclusion: The results demonstrate that curcumin promotes the functional recovery and has a neuroprotective effect on the DRG after sciatic nerve injury in the rats.