Objective: In this study, we investigated the antibacterial effects of curcumin and silver nanoparticles. The most common organism that causes the wound infection is Staphylococcus aureus, a gram positive bacterium. Owing to this fact, we selected S. aureus as a target bacteria. The main aim of this research is the investigation of curcumin and nanosilver simultaneously in the wound healing process. Materials and Methods: Curcumin has been extracted from Curcuma longa with a suitable solvent (Ethanol). After filtration, the powder was dried and the resulting yellow color powder (Curcumin) was used in the next steps. Silver nanoparticles have been synthesized by the chemical reduction of AgNo3 and characterized by means of X-ray diffraction (XRD) and scanning electron microscopy (SEM). Results: The inhibitory effects of Curcumine and Silver nanoparticles in the growth of S. aureus bacteria have been studied. In the next step we used curcumin and Silver nanoparticles simultaneously for measuring the inhibitory effects of these materials on S. aureus. The results show that curcumin-nanosilver is an effective inhibitor of growth of S. aureus bacteria and we propose the usage of curcumin-nanosilver in wound healing. Conclusion: We propose the usage of curcumin-nanosilver in wound healing.