Objective: Adult stem cells have attracted attention for clinical purposes. In this study we expected to isolate and comprehensively distinguish a subpopulation of multipotent cells within human nasal septal tissue, and performed a comparative study with other adult stem cells: Adipose Tissue-Mesenchymal Stem Cells Bone Marrow-Mesenchymal Stem Cells, and Unrestricted Somatic Stem Cells. Materials and Methods: The nasal septum derived progenitors was characterized using flowcytometery, immunofluorescence, and real-time PCR. Results: Nasal septal derived progenitors (NSPs) expressed pluripotency and mesoectodermal progenitors markers, CD106, CD166, CD90, CD105, HLA-ABC, and did not express hematopoetic markers: CD34, CD45 while particularly presented Prominin-1. NSPs showed higher clonogenic potential and longer life-span than other stem cells. NSPs differentiated into mesodermic and ectodermic lineages including osteocytes, chondrocytes, and neuron, maintaining their plasticity in differentiation pathways is another interesting feature of NSDPs. Conclusion: NSPs could be considered as an alternative cell source, which can bring them to the forefront of therapeutic purposes.