P-64: Suppressive Impact of Anethum Graveolens Consumption on Biochemical Risk Factorsof Atherosclerosis in Hypercholesterolemic Rabbits (Pages: 0-0)


Setorki M *, Rafieian-Kopaei M ,

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Objective: We aimed to determine the effects of Anethum graveolens (Dill) powder on postprandial lipid profile, markers of oxidation and endothelial activation when added to a fatty meal. Materials and Methods: In an experimental study 32 rabbits were randomly designated into 4 diet groups: normal diet, high cholesterol diet (1%), high cholesterol diet plus 5% (w/w) dill powder and high cholesterol diet plus lovastatin (10mg/kg bw). The concentrations of glucose, total cholesterol (TC), LDL cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), fibrinogen, Factor Cell Journal(Yakhteh), Vol 13, Suppl 2, Spring 2011 52 Abstracts of the 2nd National and 1st Int. Congress on "Cellular and Molecular Advances in Non-Contagious Diseases" VII, apolipoprotein B (ApoB), nitrite and nitrate were measured in blood samples following 15 hours of fasting and 3 hours after feeding. Results: Concurrent use of Anethum graveolens powder or lovastatin significantly decreased ALT, TC, glucose, fibrinogen and LDL-C values in comparison with hypercholesterolemic diet group (p<0.05). Consumption of Anethum graveolens or lovastatin did not change factor VII, ApoB, nitrite and nitrate levels significantly in comparison with hypercholesterolemic diet group. Intake of Anethum graveolens significantly decreased serum AST compared to hypercholesterolemic diet. Conclusion: This study indicates that Anethum graveolens might have some protective values against atherosclerosis and that it significantly affects some biochemical risk factors of this disease. Our findings also confirm the potential harmful effects of oxidized fats and the importance of dietary polyphenols in the meal