Evaluation of Oogenesis Aspects in Neonatal and Adult Mice after Toloaldoxime Treatment


Mohammad Fazeltabar Malekshah, M.Sc, 1,*Mahsa Sedighi, M.Sc, 2Kazem Parivar, Ph.D, 3Homa Mohseni Kouchesfahani, Ph.D, 3Mohamadali Bigdeli, Ph.D, 4
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Faculty of New Science and Technology, Tehran University, Tehran, Iran
Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Faculty of Chemistry, Tarbiat Moalem University, Tehran, Iran
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Faculty of New Science and Technology, Tehran University, Tehran, Iran
Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Faculty of Chemistry, Tarbiat Moalem University, Tehran, Iran
*Corresponding Address: P.O.Box: 16635-148 Department of Embryology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran Email:mohammad_3837@yahoo.com
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Abstract

Objective

Oximes are important materials in organic chemistry. Synparamethyl benzal- dehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female Balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs.

Materials and Methods

In experimental study, we studied the effects of toloaldoxime on ovary growth and gonadal hormones of neonatal and adult Balb/c mice. A regression model for prediction was presented.

Results

The effects of toloaldoxime on neonatal mice were more than adult mice. The greatest effect was on the number of Graafian follicles (59.6% in adult mice and 31.83% in neonatal mice). The least effect was on ovary weight, and blood serum lev- els of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

Conclusion

According to the data obtained, toloaldoxime can be considered an anti- pregnancy substance.