The Effect of Intercourse on Pregnancy Rate in IVF Cycles A Preliminary Report

Naghibi Harat Z *, Karimian L , Yazdi P.E , Moini A , Valojerdi M.R , Akhondi M.M , Shahverdi H ,


Objective: Positive effects of sperm and seminal plasma on female genital tract embryo vitality and implantation had been explained in some animal and human experiments. But there is a doubt to advise intercourse or abstinence in infertile couples during the in-vitro fertilization (IVF) cycles. We designed a prospective controlled trial to find out the intercourse effect on intra cytoplasmic sperm injection (ICSI) cycle outcome among of 1321 fresh embryo transfer. Here we report the results of pregnancy and implantation rate in 225 cycles of carrying 496 embryos which had been included till now. Materials and Methods: A total of 225 patients undergoing IVF/ICSI treatment between October and December of 2008 were randomly allocated into the case (107 people) and the control group (105 people). It was explained in case group to have intercourse 12 to 24 hours before ovum pickup and 12 hours after embryo transfer. Control group were forbidden to have intercourse in 72 hours before until 2 weeks after embryo transfer. All embryos were cultured and transferred in the same procedures. Chemical pregnancy was established in 14 and 17days after transfer by measuring βHCG level in plasma and clinical pregnancy in 6 weeks after transfer by appearance of gestational sac in ultrasonography. Results: Among 225 patients who were participated in trial 13 cycles resulted to no embryo transfer (5.8%). Mean ages of couples duration and cause of infertility number of oocyte fertilization rate source of injected sperm and sperm parameters in each group were the same. 496 embryos in 212 people were transferred totally which resulted in 64 pregnancies (30.1%). Pregnancy rate in case group was 31.8% versus 28.6% in control group; the difference was not statistically significant. Both βHCG level differences were significant between groups (p