Maternal Lead Acetate Exposure Affects Postnatal Development of Ovarian Follicles in Wistar Rats (Pages: 0-0)

Dorostghoal M *, Moazedi , Moattari M ,


Objective: During the last decades the environmental contamination by lead generated by human activities has become an evident concern. So effects of lead acetate were studied on histomorphometric structure of ovary during postnatal development in Wistar rats. Materials and Methods: The female pups randomly divided in control and experiment groups. The mothers of experiment groups received 100 and 300 mg/L/day lead acetate via drinking water during lactation. The ovaries of pups were removed at 3 months after birth their weights recorded and were fixed in Bouin’s solution. Followed tissue processing 5-6 µm paraffin sections were stained with haematoxylin-eosin and then number diameter and surface area of primordial primary secondary graffian and atretic follicles were estimated in control and experiment groups. Results: The results showed that the means of ovary weights in low and high doses groups decrease at 3 months after birth in comparison with control group. Microscopic results indicated that number of primordial and atretic follicles increased significantly (p