Protective Effect of Melatonin on Myleran-induced Changes in Testicular Damage and Sperm Characteristics in Mice

Faghani Langroudi M *, Ghasemi F.M , Nasiri E , Bahadori M.H ,


Objective: The aim of this study was to investigate the possible protective role of melatonin on myleran induced spermiotoxicity using quantitative histopathological approches and study of sperm parameters. Materials and Methods: Male adult NMRI mice were divided into four groups. The control group received physiological saline; animals in group A received a single dose of myleran 20 mg/kg intraperitoneally. Animals in group B were treated with melatonin 10 mg/kg intraperitoneally. Melatonin was administered for 5 days. Group C received a 5 day of melatonin following administration of myleran. 35 days after the treatment all animals were killed and the traits of sperm characteristics testicular histopathological and quantitative findings were determined. Results: Myleran decreased sperm concentration (p