Objective: sperm fertilization potential depends on factors such as sperm count motility and morphology. A variety of factors including free radicals may disturb the sperm parameters. Elements such as vitamins C & E and polyphenols have anti-oxidental effects. Since sperms are poor in combating with free radicals; the aim of this study is to determine the effect of pomegranate juice (PJ) on sperm parameters (count morphology motility) and fertility potential in mice. Materials and Methods: in this experimental study 20 male mice were studied with regard to their sperm parameters and fertility potential. Sperms were categorized into three groups with regards to their motility: progressive non-progressive immotile. Morphology consisted of normal and abnormal sperms. Mice were divided into control group (n=10) and experimental group (n=10) randomly. The experimental group received 20% pomegranate juice for 1 month (duration of spermatogenesis). We took one generation from each group to study the fertility rate. After autopsy a sample from the tail of epididymis region was taken to test the sperm parameters by light microscope. SPSS software version 14.0 and mann-whitney u test was used Results: The results showed that PJ consumption increased sperm count from (34.2 ± 15.1) in control group to (49.7 ± 13.6) in case group (p=0.014) also the rate of non progressive motility in case group decreased when compared with control group (p=0.007). In addition the normal morphology of the case group improved significantly (p=0.001). The rate of fertility potential increased from 5.5 ± 3.3 in controls to 10.0 ± 1.3 in case mice (p=0.007). Conclusion: PJ is able to improve the quality of sperm parameters as well as fertility potential in mice. Probably intake of this antioxidant by infertile men improves the quality of their sperm parameters.