Melatonin Improves Quality of Seminiferous Tubules and Sperm Characteristics of Acetyl Salicylate Acid Treated Male Mice


Khajeh Jahromi S *, Ghasemi F.M , Hedayati M , Hemadi M ,

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Objective: Melatonin is a potent physiological scavenger of hydroxyl radicals. In the present study we aimed to demonstrate the effect of melatonin on testicular damage and sperm parameters deficiency induced by Acetyl salicylate acid(ASA) in adult male mice. Materials and Methods: Male NMRI mice were divided into 4 groups: 1) control 2) ASA treated group 3) melatonin treated group 4) Melatonin-ASA treated group. ASA were administered in dose of 160mg/kg orally for 14 days. Melatonin were administered in dose of 10 mg/kg for 5 days intraperitoneally. Control mice were received vehicle (phosphate buffer) orally. The animals were sacrificed and their testes dissected 15 days after the treatment. Evaluations were made by determining Johnson's score epididymal sperm content and sperm morphology and testis volume. Statistical analysis was performed by ANOVA test. Results: ASA treated mice showed a reduction in Johnson's score sperm content (p