Compairing Effect of Gabapentin and Brofen on Dysmenorrhea in Infertile Patients, A Pprospective Randomized Study (Pages: 0-0)

Fotouhi E *, Yasini Sh , Razavi K ,


Objective: Dysmenorrhea is a common phenomenon before periodic cycles.medical treatment with NSAIDs may be controled it very weak.but the usage of NSAIDs have some limitation and side-effects.One of the methods of decrease pain is prophylaxy treatment.the purpose of this study was compairing effect of Gabapentin as a dopamin-agonist and Brofen as a NSAIDs for prophylaxy to decrease dysmenorrhea. Materials and Methods: In doube blind randomized study of 100 infertile patients with severe dysmenorrhea, for 3-5 days before starting the pain of periods 50 were randomized to treatment with Gabapentin and 50 to treatment with Brofen.Levels of pain and need to analgesic were measured before and after periods in two groups. Baseline clinical and demographic characteristics were measured. Results: The patients consisted of 100 infertile females, with a mean age of 30 ± 9 years. There were significant differences in levels of pain (3.2 ± 0.33 vs 1.5 ± 0.4 mg/dL, p=0.043) concentrations, or need to analgesic (52 ± 12.8 vs 52 ± 12.8 mL/min, p=0.039) in Gabapentin treatment group. Member of patients who was refered to clinical office was significantly longer in the Brofen group than in the treated group with Gabapentin(3.9 ± 1.5 vs 2.6 ± 0.7 days, p