Objective: PCOS is the most common endocrinopathic and reproductive disorders in women. The pathogenesis of PCOS is still controversial. There has long been an association of abnormal gonadotropin secretion with this syndrome. Hyperandrogenemia is principally ovarian in origin although the adrenal gland may contribute. During reproductive age, PCOS is associated with relevant reproductive morbidity including menstrual irregularity, anovulation, infertility, increased pregnancy loss, and complications of pregnancy. The goal of this research, influential immediate medical therapy after LOD. Materials and Methods: This prospective clinical research evaluates the multiple influential factors on LOD outcomes, in 177 infertile Pcos ladies, during 4 years. 77.6% was primary infertility, 20.4% secondry, 2% unknown cause. Women’s average age is 27 and her husband 33. After evaluation of semen analysis, and ruled out other causes of hyperandrogenemia, Metformin and Clomiphene were prescribed for 3 months, if no response, HSG was performed for detection of tubal patency, then gonadotropins were added to previous drugs. IUI was tried in 21.7% of patients. TVS for follicular monitoring was performed. The data were analyzed with SPSS software. LOD was end goal to reduce the amount of androgen-producing tissue, and was continuing medical therapy immediately. Results: No accessible 44 patients, therefore from 133 pcos ladies, 76 conception(55.6%), 49.7% term pregnancy, 5.9% abortion, due to LOD operation, and immediate medical therapy Conclusion: Medical prescription, immediately after LOD was suggested, because prevention of recurrent increased androgenemia and gonadoropins, therefore, fertility chance will be improved but, this research will be necessitated for more study.