Breast Cancer and History of Infertility


Sajadian A *, Olfat Bakhsh , Mehrdad N ,

0

Objective: Infertility has been recognized by the WHO as a problem affecting between 15% and 20% of couples in developed countries. Several cohort studies of infertile women have reported an incidence of breast cancer similar to that of the general population. Breast cancer is associated with several risk factors such as infertility, Hormone therapy, late age at menopause, early age at menarche and late age at first full term pregnancy. Most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in breast cancer risk development. Materials and Methods: In a cross- sectional designed study, we assessed reproductive history for 665 breast cancer patients who treated in between January. 1997 and March.2009, Iranian Center for Breast Cancer (ICBC), Tehran, Iran. We retrieved demographic and reproductive characteristics (such as, age of menarche, history of hormone therapy, age at full term pregnancy, and menopausal status from the medical records of ICBC. Results: Among 665 breast cancer patients with reproductive history, 24 (3.7%) had history of infertility. The mean age at the time of diagnosis was 46.4 years (SD = 11.3), most of them were married (N=645) (88%) and educated up to high school (67%). There were significant differences between early age of menarche (p