Objective: In this cross sectional study potential association between of VEGF gene 460, 1154, 405 polymorphisms and OHSS was evaluated Materials and Methods: A total of 160 patients who were candidate for IVF/ICSI were enrolled in this study. Among them 80 patients had OHSS and 80 patients were normoresponse to ovulation induction All patients were stimulated by long agonist protocol. , one blood sample ( 5 ml) was collected from each patient. Genomic DNA was extracted from peripheral blood using phenol – cholorophem method. Polymerase chain reaction- restriction fragment length polymorphism analysis was used to analyse the VEGF 460, 405, 1154 genotype of OHSS patients and normoresponder controls. Results: There was no significant differece in genotype frequency and allel frequency of 460 polymorphism between two groups. other result will be presented in congress. Conclusion: The association of the VEGF 460 polymorphism and OHSS is weak. other result will present in congress.