Cytogenetic Analyses of Child with Paroxysm


Nasiri F *, Manouchehri F , Mortezapour F.R.F , Rahnama M , Zamanian M , Mahjoubi F ,

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Objective: Investigation Here we report a male child with paroxysm referred to our laboratory for cytogenetic. Materials and Methods: lymphocyte cultures from the patients were set up in RPMI1640 supplemented with 20% FBS.high resolution chromosome banding was performed in all subject. Results: G banding revealed an apparently balanced reciprocal translocation between chromosome 4 and 10. The karyotype was ascertained as :46,XY,t(4;10)(q21;q26.2) Conclusion: The patient was hyperactive but mentally normal. The parents had first degree consanguineous marriage. Chromosom analysis was performed on preparation made from peripheral blood using standard protocol. G banding revealed an apparently balanced reciprocal translocation between chromosome 4 and 10. The karyotype was ascertained as :46,XY,t(4;10)(q21;q26.2) The parents had normal karyotyepe. The abnormality present in this child could be caused by the possible deletion of some of the important genes located on regions involved in these breakpoints or it can be just a coincidence