The Comparison of The Effects of Silybin and
Silybin-Phosphatidylcholine on Viability and
ESR Expression in Human Breast Cancer
T47D Cell Line
Silybin is a polyphenol with anti-oxidant and anti-cancer properties. The poor
bioavailability of some polyphenols can be improved by binding to phosphatidylcholine. In
recent years, studies have been conducted to evaluate the anti-cancer effect of silybin.
We studied the effect of silybin and silybin-phosphatidylcholine on
Materials and Methods
In this experimental study, a 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide test (MTT test) was used to determine doses for cell treatment, and the gene expression was analyzed by real-time reverse transcriptase-polymerase chain reaction (real-time RT- PCR).
Significant dose- and time-dependent cell growth inhibitory effects of silybin and
silybin-phosphatidylcholine along with
This study suggests that silybin and silybin-phosphatidylcholine down-regulate