I-67: Embryonic Stem Cell Research at Royan Institute (Pages: 0-0)


Zare Mehrjerdi N , Hosseini Salekdeh S.Gh , Baharvand H* *, Totonchi M , Nasr-Esfahani MH , Taei A , Mollamohammadi S , Karbalaie Kh , Pakzad M , Kiani S , Hatami M , Rezaei M , Shahsavani M , Farrokhi A , Tanhaei S , Pirouz M , Hemessi K , Azizi H , Seifi A , Nemati Sh , Pouya A , Moradmand B , Pournasr B , Rabbani R , Karamali F ,

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Embryonic stem cells derived from a preimplantation embryo appear to have an unlimited capacity to self-renew in cell culture, and they are also able to differentiate into hundreds of adult cell types. Human embryonic stem cell lines offer a platform technology that has the potential to elucidate the molecular mechanisms that determine adult cell fate, generate cellular models for discovery of new drugs, and create populations of differentiated cells for novel transplantation therapies. Here, our studies about embryonic stem cell establishment, differentiation into cell types representing the three embryonic germ lineages, and their potential applications will be summarized.