P-27:Foenicullum Vulgare Alcoholic Extract PromotesFolliculogenesis in Female Albino Mice (Pages: 0-0)

Khazaei MR , Montaseri A , Khazaei M* *,


Objective: The aim of the present study is to investigate the effects of Foenicullum Vulgare (FVE) on the folliculogenesis in female albino mice. FVE is used in traditional medicine for its antiseptic, palliative, antiinflammatory and estrogenic effects. Materials and Methods: Twenty female albino mice divided into 4 groups. Groups 1 and 2(Cases) received FVE alcoholic extract at dose of 100 and 200 mg/kg/day for five days, group 3 and 4 were administered ethanol and normal saline respectively as same dose as cases. Animals in all groups sacrificed on the 6th day of study and their ovaries dissected out and prepared for histological examinations. Results: There was a significant increase in the number of graffian, antral and multilaminar follicles in the present of 100 and 200mg/kg doses of FVE extract, but there was no significant difference in follicle numbers among the FVE doses. Also there was no significant difference in the number of unilaminar primary follicles between all case and control groups Conclusion: FVE alcoholic extract had folliculogenesis effect on mouse ovary and produce significant increase in the number of follicles.