MicroRNA-Based Linkage between Aging and Cancer: from Epigenetics View Point


Saeid Saeidimehr, M.D., M.P.H., 1Ammar Ebrahimi, Ph.D, 2Najmaldin Saki, Ph.D, 3Parisa Goodarzi, M.Sc, 4Fakher Rahim, Ph.D, 3,*
Naft Grand Hospital, Ahvaz, Iran
Department of Medical Biotechnology, School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran
Health Research Institute, Thalassemia and Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
Naft Grand Hospital, Ahvaz, Iran
Department of Medical Biotechnology, School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran
Health Research Institute, Thalassemia and Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
*Corresponding Address: P.O.Box: 61537-15794 Health Research Institute Thalassemia and Hemoglobinopathy Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Email:Bioinfo2003@gmail.com
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Saeidimehr Saeid, Ebrahimi Ammar, Saki Najmaldin, Goodarzi Parisa, Rahim Fakher. MicroRNA-Based Linkage between Aging and Cancer: from Epigenetics View Point. Cell J. 2016; 18(2): 117-126.

Abstract

Ageing is a complex process and a broad spectrum of physical, psychological, and social changes over time. Accompanying diseases and disabilities, which can interfere with cancer treatment and recovery, occur in old ages. MicroRNAs (miRNAs) are a set of small non-coding RNAs, which have considerable roles in post-transcriptional regulation at gene expression level. In this review, we attempted to summarize the current knowledge of miRNAs functions in ageing, with mainly focuses on malignancies and all underlying genetic, molecular and epigenetics mechanisms. The evidences indicated the complex and dynamic nature of miRNA-based linkage of ageing and cancer at genomics and epigenomics levels which might be generally crucial for understanding the mechanisms of age-related cancer and ageing. Recently in the field of cancer and ageing, scientists claimed that uric acid can be used to regulate reactive oxygen species (ROS), leading to cancer and ageing prevention; these findings highlight the role of miRNA-based inhibition of the SLC2A9 antioxidant pathway in cancer, as a novel way to kill malignant cells, while a patient is fighting with cancer.