Up-Regulation of FOXC2 and FOXQ1 Is Associated with The Progression of Gastric-Type Adenocarcinoma


Farzad Soleimani, M.Sc, 1Mohammadreza Hajjari, Ph.D, 2Bahram Mohammad Soltani, Ph.D, 1Mehrdad Behmanesh, Ph.D, 1,*
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
*Corresponding Address: P.O.Box: 14115-154 Department of Genetics Faculty of Biological Sciences Tarbiat Modares University Tehran Iran Email:behmanesh@modares.ac.ir
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Soleimani Farzad, Hajjari Mohammadreza, Mohammad Soltani Bahram, Behmanesh Mehrdad. Up-Regulation of FOXC2 and FOXQ1 Is Associated with The Progression of Gastric-Type Adenocarcinoma. Cell J. 2017; 19(Suppl 1): 66-71.

Abstract

Objective

Forkhead box (FOX) proteins are important regulators of the epithelial-to-mesenchymal transition (EMT), which is the main mechanism of cancer metastasis. Different studies have shown their potential involvement in progression of cancer in different tissues such as breast, ovary and colorectum. In this study, we aimed to analyze the expression of genes encoding two FOX proteins in gastric adenocarcinoma.

Materials and Methods

In this experimental case-control study, the expression of FOXC2 and FOXQ1 was examined in 31 gastric adenocarcinoma tumors and 31 normal adjacent gastric tissues by reverse transcription polymerase chain reaction (PCR).

Results

The expression of both genes was significantly up-regulated in gastric adenocarcinoma tumors compared with the normal tissues (P<0.05). The differential expression of these two genes was also correlated with the grade of tumors (P<0.01).

Conclusion

We show that up-regulation of FOXC2 and FOXQ1 are likely to be involved in the progression of gastric adenocarcinoma.