Punica granatum L. Fruit Aqueous Extract Suppresses Reactive
Oxygen Species-Mediated p53/p65/miR-145 Expressions
followed by Elevated Levels of irs-1 in
Reactive oxygen species (ROS) is an apoptosis inducer in pancreatic β-cells that stimulates p53/p65
mediated microRNA (miR)-145 expression.
Materials and Methods
In this experimental study, diabetic rats received different doses of PGE. The effects of the
PGE polyphenols were examined through a long-term PGE treatment period model, followed by an evaluation of the
plasma and tissue contents of free fatty acids (FFAs), triglycerides (TG), and glycogen compared with diabetic controls
(DC)and normal controls (NC). We used real-time polymerase chain reaction (PCR) to investigate the modulation of
There was a noticeable reduction in fasting blood glucose (FBG) and ROS generation compared to DC.
We observed marked decreases in
PGE administration downregulated miR-145 levels in Alloxan-diabetic Wistar rats by suppression of