Development of Insulin Resistance through Induction
of miRNA-135 in C2C12 Cells
Micro-RNAs (miRNAs) are a class of posttranscriptional regulators that play crucial roles in various biological processes. Emerging evidence suggests a direct link between miRNAs and development of several diseases including type 2 diabetes (T2D). In this study, we aimed to investigate the effect of predicted miRNA and target genes on insulin resistance.
Materials and Methods
This experimental study was conducted on the C2C12 cell line.
Using bioinformatics tools miRNA-135 and two respective target genes-insulin receptor
It was determined that
Our data indicated no change on the