Satellite Cells Contribution to Exercise Mediated Muscle Hypertrophy and Repair

(Pages: 473-484)
Behzad Bazgir, Ph.D, 1,2Rouhollah Fathi, Ph.D, 2Mojtaba Rezazadeh Valojerdi, Ph.D, 2,3Paul Mozdziak, Ph.D, 4Alireza Asgari, Ph.D, 1,5,*
Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Physiology Graduate Program, North Carolina State University, Raleigh, NC, USA
Aerospace and Subaquatic Medicine Faculty, Aerospace Medicine Research Center, AJA Medical Sciences University, Tehran, Iran
Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Physiology Graduate Program, North Carolina State University, Raleigh, NC, USA
Aerospace and Subaquatic Medicine Faculty, Aerospace Medicine Research Center, AJA Medical Sciences University, Tehran, Iran
*Corresponding Address: P.O.Box: 1435116471 Exercise Physiology Research Center Baqiyatallah University of Medical Sciences Tehran Iran Email:asgari@bmsu.ac.ir
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Bazgir Behzad, Fathi Rouhollah, Rezazadeh Valojerdi Mojtaba, Mozdziak Paul, Asgari Alireza. Satellite Cells Contribution to Exercise Mediated Muscle Hypertrophy and Repair. Cell J. 2017; 18(4): 473-484.

Abstract

Satellite cells (SCs) are the most abundant skeletal muscle stem cells. They are widely recognized for their contributions to maintenance of muscle mass, regeneration and hypertrophy during the human life span. These cells are good candidates for cell therapy due to their self-renewal capabilities and presence in an undifferentiated form. Presently, a significant gap exists between our knowledge of SCs behavior and their application as a means for human skeletal muscle tissue repair and regeneration. Both physiological and pathological stimuli potentially affect SCs activation, proliferation, and terminal differentiation the former category being the focus of this article. Activation of SCs occurs following exercise, post-training micro-injuries, and electrical stimulation. Exercise, as a potent and natural stimulus, is at the center of numerous studies on SC activation and relevant fields. According to research, different exercise modalities end with various effects. This review article attempts to picture the state of the art of the SCs life span and their engagement in muscle regeneration and hypertrophy in exercise.