RORA and Autism in The Isfahan Population: Is
There An Epigenetic Relationship
(Pages: 540-546)
Abstract
Objective
Autism is a neurodevelopmental disorder characterized by difficulty in verbal
and non-verbal communication, impaired social interaction, and restricted and repetitive
behavior. It has been recently introduced as a multigenic disorder with significant epigenetic effects on its pathology. Recently, epigenetic silencing of retinoic acid receptor-
related orphan receptor alpha (
Materials and Methods
The methylation status of a 136 bp sequence of a GpG island
(encompassing 13 CpG sites) in the
Results
This study revealed no methylation in the examined promoter regions in both
autistic and normal children, with the melting curve of all studied samples being comparable to that of the non-methylated control. The results of MCA-Meth analysis were also
consistent with qRT-PCR results. We therefore observed no significant difference in the
levels of
Conclusion
The methylation of the