Melatonin Modifies Histone Acetylation during
In Vitro Maturation of Mouse Oocytes
We evaluated the effect of melatonin, as a potent antioxidant agent, on glutathione (GSH) and reactive oxygen species (ROS) levels, as well as histone H3 lysine 9 (H3K9), and H4 lysine 12 (H4K12) acetylation when added to oocytes culture medium.
Materials and Methods
In this experimental study, two
The H4K12 acetylation and ROS levels were significantly higher in the oocytes matured in the in
vitro group compared to the
Exogenous melatonin improves the competence of mouse oocytes during