Coadministration of Dexamethasone and Melissa officinalis
Has Neuroprotective Effects in Rat Animal Model
with Spinal Cord Injury
Spinal cord injury (SCI) causes inflammation, deformity and cell loss. It has
been shown that
Materials and Methods
Thirty six adult male Wistar rats were used in this experimental study. The weight-drop contusion method was employed to induce spinal cord injury in rats. DEX and MO were administrated alone and together in different treatment groups. Intra-muscular injection of DEX (1 mg/kg) was started three hours after injury and continued once a day for seven days after injury. Intra-peritoneal (I.P) injection of MO (150 mg/ kg) was started one day after injury and continued once a day for 14 days.
Our results showed motor and sensory functions were improved significantly in
the group received a combination of DEX and MO, compared to spinal cord injury group.
Mean cavity area was decreased and loss of lower motor neurons and astrogliosis in the
ventral horn of spinal cord was significantly prevented in the group received combination
of DEX and
Results showed that combination of DEX and MO could be considered as a neuroprotective agent in spinal cord injury.